Clinical Chemistry and Endocrinology

Major Research Interests

Research

The research interest of the Department of Clinical Chemistry and Endocrinology focuses on the following areas and most research activities have been funded by the NHMRC.

1/ Evidence-based evaluation of medical tests:

This activity is carried out in collaboration with the Test Evaluation Working Group of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM –   https://www.eflm.eu/site/page/a/1158). Prof Horvath was founding chair of this working group between 2011 and 2015 and currently is still an active consultant to the group that develops guidance documents and tools for evaluating the clinical performance and clinical utility of new biomarkers. Within this group, Prof Horvath has established and currently chairs a new international task force that aims to define analytical performance specifications for medical tests based on evidence from outcome studies. Both groups’ work has been supported by an EFLM grant. For more information see: https://www.eflm.eu/site/page/a/1396

2/ Patient safety and management of critical laboratory results:

This work is carried out in collaboration with the Australian Institute of Health Innovation at Macquarie University as part of a 5-year NHMRC grant aiming at better communication and clinical follow-up of tests results. Craig Campbell, a part-time PhD student in the department, is heavily involved in this project.  See details at: http://aihi.mq.edu.au/project/improving-test-result-communication-management-and-follow

This research activity also supports a national harmonization project in collaboration with the Australasian Association of Clinical Biochemistry (AACB) and the Royal College of Pathologists of Australasia (RCPA). Prof Horvath and Craig Campbell are founding members of this joint working party and actively take part in developing national guidance documents on the management of critical laboratory results. For details see: https://www.aacb.asn.au/aboutus/harmonisation-committees and https://www.aacb.asn.au/aboutus/2018-harmonisation-workshop-reports

 3/ Overdiagnosis and rational test utilization:

This activity is carried out in collaboration with the University of Sydney and Bond University as part of a 5-year NHMRC program grant called Wiser Healthcare. Prof Horvath is an associate investigator in this program. For details see: http://wiserhealthcare.org.au/

4/ Applied research related to laboratory testing:

This activity covers various laboratory testing related smaller projects mostly covered by departmental research funds or an NHMRC grant. Examples include: development of tests using LCMS/MS technology, establishment of reference intervals and decision limits for various laboratory tests, eAlerts for acute kidney injury, harmonisation of steroid measurements and reference intervals.

5/ Bone and calcium metabolism and endocrinology:

This activity is spearheaded by Prof. Chris White who holds numerous external and internal research grants and manages a broad range of clinical collaborations.

Education

With an emphasis on internal and external education, scientific staff and registrars within the department are provided with the opportunity to attend regular education sessions, in house and within the broader hospital community. Departmental staff regularly attend and present at hospital grand rounds and present lectures and posters at local AACB and RCPA conferences, or internationally at EFLM, IFCC (International Federation of Clinical Chemistry and Laboratory Medicine), AACC (American Association of Clinical Chemistry) and Endocrinology Society meetings. Members of staff are also engaged in high degrees in both Masters and PhD research programs.

In 2015-2016, Prof Horvath, as one of the 3 senior editors, has been editing the 6th edition of the Tietz Textbook of Clinical Chemistry and Molecular Diagnostics and in 2017-2018 the 8th edition of the Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics.

  1. Current Researcher: Ben Matthews – Chromatography
  1. Senior Scientist Craig Campbell – Part time PhD student at Macquarie University

 

Recent Grants

 

        Year

   Grant Source

        Title

    Funds ($)

    Contribution

  2016-2019

NHMRC Partnership Project Shared Grant

Delivering safe and effective test result communication, management and follow-up

    883,358

  A R Horvath CI

  2016-2019

NHMRC Grant

Creating sustainable health care: ensuring new diagnostics avoid harms

  2,497,658 

  A R Horvath  AI

Research Papers

Contacts